Macromolecular Crystallography

in the labs of

The research laboratories form a subgroup of the Institute of Molecular Biology interested in macromolecular structure and function. Members of the group take advantage of a wide array of biochemical and biophysical techniques to study enzyme structures, protein-protein and protein-substrate interactions, protein folding, cell signalling, RNA splicing and site selection and nuclear receptor regulatory mechanisms. The laboratories share common facilities including a state of the art biotechnology laboratory (mass spectrometery, sequencing and other analytical tools) as well as an array of X-ray diffraction and computing equipment. The Matthews' group is concerned primarily with protein folding, stability, and protein-DNA interactions. The Remington group focuses on structure-function relationships in several enzyme systems and in a variety of fluorescent proteins. The Prehoda group is interested in the molecular mechanisms of signal transduction in a range of systems. The Berglund group studies intron-pre-mRNA relationships involved in RNA splicing. Finally, the Darimont group is interested in nuclear receptor-dependent signaling pathways. Crystal structure analysis of macromolecules relevant to each group's research is regarded as an essential tool for the advancement of the field.

Institute of Molecular Biology
1229 University of Oregon
Eugene, OR 97403
Tel: 541-346-2572
Fax: 541-346-5870

Department of Physics
1371 East 13th Avenue
Eugene, OR 97403
Tel: 541-346-4571
Fax: 541-346-5861

Department of Chemistry
91 Klamath Hall
University of Oregon
Eugene, OR 97403-1253
Tel: 541-346-4601